Collaborators

Science Advisors

Prof. Alberto D. Podjarny, Ph.D.

Director of Research

Department of Integrative Biology, IGBMC, CNRS, INSERM

Université de Strasbourg, 1 rue Laurent Fries, 67404 Illkirch, France

www.igbmc.fr/research/3/team/113

Alberto D. Podjarny is the Research Director for the Intergrated Structural Biology group, CNRS at the Institute of Genetics and Molecular and Cellular Biology (IGBMC) in Illkirch, France. His primary scientific interest is the development of crystallographic methodology and its application to biological problems, mainly neutron diffraction and ultra high resolution crystallography.

He is particularly interested in the subatomic resolution X-Ray crystallography for the structural study of pharmaceutical targets and its application to rational drug design.  He is an active member of the research community with more than 100 publications in peer-reviewed journals, author of 1 book and organizer of numerous symposia.

Prof. Anna Marie Pyle

William Edward Gilbert Professor of Molecular, Cellular and Developmental Biology

Professor of Chemistry, Yale University and HHMI Investigator

Yale University and Howard Hughes Medical Institute, New Haven, CT

www.pylelab.org

Anna Marie Pyle is the William Edward Gilbert Professor of Molecular, Cellular and Developmental Biology and Professor of Chemistry at Yale University. She obtained her undergraduate degree in Chemistry from Princeton University and her Ph.D. in Chemistry from Columbia University in 1990. Dr. Pyle was a postdoctoral fellow in the laboratory of Thomas Cech.

Dr. Pyle has received many awards, she has served in a leadership capacity at Yale and is author of more than 130 publications.  Dr. Pyle is interested in the molecular structure and mechanisms of enzymes that play a role in innate immune response and pathogen infection.
Her lab has pioneered enzymological and structural studies on the human RIG-I innate immune sensor and the NS3 helicase-protease from Hepatitis C virus.  In the Pyle lab, pre-steady-state kinetic analysis is coupled with crystallographic and mutational studies to provide a unified framework for understanding enzyme mechanism.

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